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      <title>Self-Hosted Microscope Automation Platforms: Micro-Manager vs pymmcore-plus vs PYME</title>
      <link>https://www.pistack.xyz/posts/2026-06-14-self-hosted-microscope-automation-instrument-control-guide/</link>
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      <description>&lt;h2 id=&#34;introduction&#34;&gt;Introduction&lt;/h2&gt;&#xA;&lt;p&gt;Modern microscopy has moved far beyond looking through eyepieces. Today&amp;rsquo;s research microscopes are computer-controlled instruments capable of automated multi-channel acquisition, time-lapse imaging, z-stack capture, and high-content screening. However, commercial microscope control software from manufacturers like Zeiss (ZEN), Leica (LAS X), and Nikon (NIS-Elements) is proprietary, expensive, and locks you into specific hardware ecosystems.&lt;/p&gt;</description>
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