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      <title>Self-Hosted RNA Secondary Structure Prediction: ViennaRNA vs RNAstructure vs R2DT vs forna</title>
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      <description>&lt;h2 id=&#34;introduction&#34;&gt;Introduction&lt;/h2&gt;&#xA;&lt;p&gt;RNA molecules are not just passive messengers carrying genetic information — they fold into complex three-dimensional structures that determine their function. From catalytic ribozymes to regulatory riboswitches, RNA secondary structure governs how these molecules interact with proteins, small molecules, and other nucleic acids. Predicting RNA secondary structure from sequence alone has been a foundational challenge in computational biology for over four decades.&lt;/p&gt;</description>
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