https://www.pistack.xyz/tags/methylation/ Recent content in Methylation on Pi Stack Hugo en-us Sat, 13 Jun 2026 00:00:00 +0000 https://www.pistack.xyz/posts/2026-06-13-self-hosted-epigenomics-data-analysis-macs3-deeptools-methylkit/ Sat, 13 Jun 2026 00:00:00 +0000 https://www.pistack.xyz/posts/2026-06-13-self-hosted-epigenomics-data-analysis-macs3-deeptools-methylkit/ <p>Epigenomics is the study of heritable changes in gene expression that do not involve alterations to the DNA sequence itself. Unlike genomics — which focuses on the raw nucleotide sequence — epigenomics examines the chemical modifications and chromatin architecture that control which genes are active in which cell types. For bioinformaticians and computational biologists, self-hosting epigenomics analysis tools means reproducible workflows, data sovereignty for sensitive patient-derived datasets, and the ability to scale analysis pipelines across institutional compute clusters.</p>