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    <title>Genome-Alignment on Pi Stack</title>
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      <title>Self-Hosted Comparative Genomics Pipelines: Cactus vs MUMmer vs LASTZ vs SibeliaZ</title>
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      <description>&lt;h2 id=&#34;introduction&#34;&gt;Introduction&lt;/h2&gt;&#xA;&lt;p&gt;Comparative genomics — the systematic comparison of whole genomes across species — reveals evolutionary relationships, identifies conserved functional elements, and tracks genomic rearrangements. With sequencing costs continuing to drop and thousands of new genomes published annually, the computational tools for aligning and comparing entire genomes have become essential infrastructure for modern biology.&lt;/p&gt;</description>
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