https://www.pistack.xyz/tags/computational-biology/ Recent content in Computational-Biology on Pi Stack Hugo en-us Wed, 10 Jun 2026 00:00:00 +0000 https://www.pistack.xyz/posts/2026-06-10-self-hosted-neuroscience-simulation-neuron-nest-brian2/ Wed, 10 Jun 2026 00:00:00 +0000 https://www.pistack.xyz/posts/2026-06-10-self-hosted-neuroscience-simulation-neuron-nest-brian2/ <h2 id="introduction">Introduction</h2> <p>Understanding how the brain computes requires simulating neuronal networks at multiple scales—from individual ion channels in a single dendrite to populations of thousands of interconnected neurons. Three open-source simulators have become the standard tools for computational neuroscience: <strong>NEURON</strong> (biophysically detailed single-neuron models), <strong>NEST</strong> (large-scale point-neuron networks), and <strong>Brian2</strong> (rapid prototyping with mathematical clarity).</p>