https://www.pistack.xyz/tags/blast/ Recent content in Blast on Pi Stack Hugo en-us Sat, 13 Jun 2026 00:00:00 +0000 https://www.pistack.xyz/posts/2026-06-13-self-hosted-biological-sequence-search-engines-sequenceserver-diamond-mmseqs2-hmmer/ Sat, 13 Jun 2026 00:00:00 +0000 https://www.pistack.xyz/posts/2026-06-13-self-hosted-biological-sequence-search-engines-sequenceserver-diamond-mmseqs2-hmmer/ <h2 id="introduction">Introduction</h2> <p>Sequence similarity searching is the most fundamental operation in bioinformatics. Whether you&rsquo;re annotating a newly assembled genome, identifying protein families, or searching for homologous sequences across species, a fast and sensitive sequence search engine is essential. While many researchers rely on the NCBI BLAST web service, self-hosting your own sequence search infrastructure offers significant advantages: unlimited queries, custom databases, data privacy, and integration into automated analysis pipelines.</p>