https://www.pistack.xyz/tags/adaptive-immunity/ Recent content in Adaptive-Immunity on Pi Stack Hugo en-us Sat, 13 Jun 2026 00:00:00 +0000 https://www.pistack.xyz/posts/2026-06-13-self-hosted-immune-repertoire-analysis-immunarch-mixcr-trust4/ Sat, 13 Jun 2026 00:00:00 +0000 https://www.pistack.xyz/posts/2026-06-13-self-hosted-immune-repertoire-analysis-immunarch-mixcr-trust4/ <h2 id="introduction">Introduction</h2> <p>The adaptive immune system maintains a vast library of T-cell receptors (TCRs) and B-cell receptors (BCRs) capable of recognizing virtually any pathogen. High-throughput sequencing now allows researchers to profile these immune repertoires at unprecedented depth — but analyzing the resulting data requires specialized computational tools that can handle the unique challenges of immune receptor sequences: extreme diversity, shared gene segments, and somatic hypermutation.</p>